G6PD activator AG1
CAS No. 421581-52-4
G6PD activator AG1 ( )
Catalog No. M29654 CAS No. 421581-52-4
G6PD activator AG1 is a potent and selective glucose-6-phosphate dehydrogenase (G6PD) activator with an EC50 of 3 μΜ.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
10MG | 689 | Get Quote |
|
25MG | 1378 | Get Quote |
|
50MG | 1788 | Get Quote |
|
100MG | 2256 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
Biological Information
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Product NameG6PD activator AG1
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NoteResearch use only, not for human use.
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Brief DescriptionG6PD activator AG1 is a potent and selective glucose-6-phosphate dehydrogenase (G6PD) activator with an EC50 of 3 μΜ.
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DescriptionG6PD activator AG1 is a potent and selective glucose-6-phosphate dehydrogenase (G6PD) activator with an EC50 of 3 μΜ. G6PD activator AG1 reduces hemolysis of human erythrocytes.AG1 (50, 100, 250, 500, 750, 1000 nM) of 1μM increases the viability by 20% and the proteolytic stability of Canton G6PD in SH-SY5Y cells. AG1 has no effect when G6PD was knocked down by siRNA, supporting the specificity of AG1 toward G6PD.AG1 (1-5 μΜ; pre-incubated overnight) reduces the extent of hemolysis with 5 μΜ in human erythrocytes suspension (5%) exposed to either 1 mM chloroquine (CQ; 4 hours) or diamide (a GSH oxidant; 4 hours). AG1 increases GSH levels and reduced ROS levels together with increased G6PD activity under these drug-induced oxidative stress.AG1 has no effect on the dimerization or activity of several other NAD- or NADP+-dependent dimeric or tetrameric enzymes, including 6-phosphogluconate dehydrogenase (6PGD), glyceraldehyde 3-phosphate dehydrogenase (GAPDH), aldehyde dehydrogenase 2 (ALDH2), and aldehyde dehydrogenase 3A1 (ALDH3A1).
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Synonyms
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PathwayOthers
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TargetOther Targets
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RecptorIC50: 3 μΜ (G6PD)
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Research Area——
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Indication——
Chemical Information
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CAS Number421581-52-4
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Formula Weight438.7
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Molecular FormulaC24H30N4S2
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Purity>98% (HPLC)
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SolubilityDMSO : 20.83 mg/mL (47.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
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SMILESC1(CCNCCSSCCNCCC2=CNC3=C2C=CC=C3)=CNC4=C1C=CC=C4
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Chemical Name
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kaitlyn Ryan, et al. Current investigations on clinical pharmacology and therapeutics of Glucose-6-phosphate dehydrogenase deficiency. Pharmacol Ther. 2020 Dec 14;222:107788.
molnova catalog
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